Plant Extracts. Mushroom Extracts. Animal Extracts. Fruit Powder. Vegetable Powder. Vegetarian Protein. Other Products. Home Pepsin Pepsin. Pepsin is one of the principal protein degrading or proteolytic enzymes in the digestive system.
During the process of digestion, Pepsin acts on the complex dietary protein and breaks up into peptides and amino acids which can be readily absorbed by the intestinal lining. It helps in digestive disturbance in general and as a result of impaired production of gastric juice.
It acts as an adjunct in the treatment of anemic conditions, especially during slimming diet when protein intake increases. It is used as research tool in protein analysis and as digestive syrup in heart burn, acid indigestion and sour stomach.
It is also used in tablets for increasing appetite and in the preparation of cheese and other protein-containing foods. Catalog NATE Pepsin benefits and uses include:. Although pepsin is an important digestive enzyme with many benefits, there are several digestive problems that are linked to dysfunction of pepsin. These include:. Foods in your diet do not actually contain pepsin, but they can affect your production of stomach acid and digestive enzymes.
The volume you produce increases if you eat high volumes of protein. Pepsin medications and supplements are also sources of pepsin. These are used to enhance digestion of food especially proteins when someone lacks proper pepsin secretion.
They help manage conditions like pancreatitis as well. Pepsin supplements are usually produced from hog or swine pig stomachs. The product called betaine hydrochloride or betaine HCL with pepsin is recommended by some practitioners a supplemental source of hydrochloric acid for people who have low stomach acid production also called hypochlorhydria. This may help hydrochloric acid secreted by the stomach better convert pepsinogen and aid in digestion of protein.
Plus, it may offer other benefits like reducing allergies and inhibiting the overgrowth of candida. Pepsin supplements include drugs that are available as over-the-counter pills that can be taken without a medical prescription. They are available in the form of tablets, compounding powders and capsules.
The optimal pepsin dosage you should take depends on factors like your weight, height, age, diet, lifestyle and medical history. If you need a prescription-strength pepsin medicine, your doctor will decide how much you should take.
Two examples of pepsin medicines are Nuzyme Tablets and Wegazyme Syrup. If you take an over-the-counter digestive enzyme supplement, read directions carefully. For the best results, look for a high-quality digestive enzyme blend that includes a variety of different enzymes. Some products combine HCL and pepsin to boost effects.
HCL with pepsin is a great thing you can start taking on a regular basis to help heal your GI tract, fight things like acid reflux and improve low stomach acid.
HCL with pepsin is somewhat controversial, but it is typically taken while under the care of a physician. The stomach is a sack-like organ located in the left upper abdomen. When food enters the stomach, the strong muscles of the stomach's walls churn the food, mixing it with gastric juice to produce "chyme.
Tasting, smelling, seeing or just thinking about food can cause gastric glands in the stomach to secrete gastric juice. The hydrochloric acid in the gastric juice converts pepsinogen into pepsin by cleaving off a stretch of amino acids called a peptide.
This reaction requires very acidic pH, ranging between 1 to 3. The acidic environment is needed for the generation and activity of pepsin. The hydrochloric acid in the stomach generally provides a pH of about 1. The acid in the stomach causes food proteins to unfold in a process called denaturation. But the similarity with the other enzymes pictured here refers to a second type of acid. The active site of the acid proteases rely on two acidic aspartate amino acids, which activate a water molecule and use it to cleave protein chains.
These aspartates are pictured on the next page. The acid proteases have evolved to fill several functional roles in different organisms. Pepsin, shown at upper left PDB entry 5pep , is optimized for digestion of food in the acidic environment of the stomach. It is very promiscuous, cleaving proteins in many different places. Chymosin, shown at upper right PDB entry 4cms , is made by young calves to break down milk proteins. A purified form of chymosin, taken from calf stomach, has been used for centuries to curdle milk in the production of cheese.
Cathepsin D, shown at lower left PDB entry 1lyb , digests proteins inside lysozomes, the tiny stomachs inside cells. Other cellular acid proteases, such as renin not shown, PDB entry 1hrn , are designed to make very specific cuts in one particular protein, aiding in the maturation of a hormone or structural protein.
Endothiapepsin, shown at lower right PDB entry 4ape , is made by a fungus and excreted into the surrounding environment, breaking up the surrounding proteins and allowing the fungus to feed on the pieces. Image JSmol Pepsin and Pepstatin. References 1pso: Fujinaga, M. Protein Sci.
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